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Diazepam Valium is among the most successful drugs from the onset of the psychopharmacological revolution that began during the s. Efficacious in treating a wide-spectrum of CNS disorders, including anxiety and epilepsy, it set the standard for pharmacotherapy in terms of potency, onset of action, and safety. In this Review, the legacy of diazepam to chemical neuroscience will be considered along with its synthesis, pharmacology, drug metabolism, adverse events and dependence, clinical use, and regulatory issues. Anxiety disorders have been the most prevalent of all psychiatric ailments. Along with generalized anxiety disorder GAD, over 40 million people in the United States live with panic disorder, agoraphobia, post-traumatic stress disorder PTSD, obsessive-compulsive disorder OCD, or other forms of anxiety disorders. Historically, the first pharmacological treatments for anxiety consisted of using general depressants and sedatives such as alcohol, opiates, lithium bromide, and chloral hydrate. However, it was not until when the pharmacotherapy for anxiety disorders became available with a greatly improved safety profile, in contrast to the narrow therapeutic range of sedatives and hypnotics. Beginning with chlordiazepoxide 2 Librium, benzodiazepines proved to be a promising new class of potent anxiolytics without fatal adverse events. Diazepam interaction with these sites increases neuronal chloride-ion influx upon GABA binding, resulting in hyperpolarized postsynaptic membranes, thus enhancing CNS depression response to endogenous GABA.
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Valium, generically known as Diazepam, is a prescription Benzodiazepine used to treat anxiety, alcohol withdrawal, and seizures. Similar to other drugs in this class, it is also used to relieve muscle spasms and occasionally to provide sedation before medical procedures. The effects of using Valium can range from desired to debilitating, including overdose. Like most prescription medications, Valium can cause one or more potentially negative side effects. Because it directly impacts the central nervous system CNS, the medicine can express itself in a number of ways. Common effects of the drug include dizziness, drowsiness, fatigue, and light-headedness. These effects can vary in degree of strength and length of time, so someone taking the medication should avoid driving, operating heavy machinery, or any other dangerous activity that requires focus and coordination. Although rare, Valium can have other serious side effects such as memory impairment, irritability, and the engagement in unconscious actions like sleep driving, sleep calling, and sleep eating.