Mequinol and Tretinoin in combination are used to treat areas of the skin that have become darker after repeated exposure to the sun. These areas are called solar lentigines, or age or liver spots.
Mequinol is a common active ingredient in topical cosmeceutical ingredients used for skin depigmentation. As a topical drug mequinol is often mixed with tretinoin, a topical retinoid. A common formulation for this drug is an ethanolic solution of 2% mequinol and 0.01% tretinoin by mass. Dermatologists commonly prescribe the drug to treat solar lentigines, liver spots, or age spots.
Lower dosages of mequinol have been used in conjunction with a Q-switched laser to depigment skin in patients with disseminated idiopathic vitiligo. Melalong (mequinol 2%, tretinoin 0.01%) Topical cream is indicated for the treatment of solar lentigines. Melalong should only be used under medical supervision as an adjunct to comprehensive skin care and sun avoidance program where the patient should primarily either avoid the sun or use protective clothing.
Neither the safety nor effectiveness of Melalong for the prevention or treatment of melasma or postinflammatory hyperpigmentation has been established.
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